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Please use this identifier to cite or link to this item: http://hdl.handle.net/2307/428

Title: Ubiquitin-proteasome dependent regulation of p73 protein stability
Other Titles: Regolazione ubiquitina-proteasoma dipendente della stabilità proteica di p73
Authors: Scialpi, Flavia
Tutor: Lauro, Giuliana Maria
Issue Date: 16-Feb-2009
Publisher: Università degli studi Roma Tre
Abstract: Background and aim p73 is a structural and functional homologue of the tumor suppressor transcription factor p53, which binds to canonical p53 DNA-binding sites, activates transcription from p53-responsive promoters and, hence, induces cell cycle arrest and apoptosis (reviewed in Melino et al., 2002). In contrast to p53, p73 exists as several distinct protein isoforms (-) generated by alternative splicing at the C-terminal (De Laurenzi et al, 1998, 1999 and 2000). Additionally, t
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URI: http://hdl.handle.net/2307/428
Appears in Collections:T - Tesi di dottorato
Dipartimento di Biologia

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