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Please use this identifier to cite or link to this item: http://hdl.handle.net/2307/5336

Title: Prostate specific antigen (psa): from the catalytic activity to the clinical value
Other Titles: L’antigene prostatico specifico (PSA): dall’attività catalitica all’uso clinico
Authors: Tomao, Luigi
Tutor: Ascenzi, Paolo
Keywords: radical prostate
prostate cancer
psa
tumor markers
Issue Date: 16-Feb-2015
Publisher: Università degli studi Roma Tre
Abstract: Prostate-specific antigen (PSA) is a serine protease belonging to the kallikrein family and it is also known as kallikrein-related peptidase 3 (KLK3). The major physiologic substrates for PSA appear to be the gel-forming proteins in freshly ejaculated semen, semenogelin I (SgI) and semenogelin II (SgII) which are synthesized and secreted by the seminal vesicles. PSA can also cleave a number of growth regulatory proteins that are important in cancer development and survival as IGFBP, PTH-related
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URI: http://hdl.handle.net/2307/5336
Access Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Dipartimento di Scienze
T - Tesi di dottorato

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